Mechanobiology of killer immune cell movements and interactions.
Molecular Horizons Seminar - Dr. Maté Biro
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Wollongong Campus
32.G01
Cytotoxic lymphocytes can migrate rapidly and with striking versatility in a continuous search for cells to subdue. Adoptive cell transfer immunotherapies against solid cancers attempt to harness the capacity of T cells and NK cells to navigate various barriers and organs to reach the tumour and then effectively engage and kill their targets, yet the mechanisms and cellular forces that underpin their movements and interactions are incompletely understood.
Here, we investigate the intercellular signalling and mechanical forces that T cells employ to effectively hunt down and kill cancer cells. Using an integrative and multidisciplinary method encompassing advanced live-cell microscopy, image analysis, biophysics and computational modelling, we are uncovering the intricate mechanobiology of T cell-mediated tumour rejection.