Molecular Horizons Seminar - Professor Michael Kassiou

The Translocator Protein (TSPO) represents a promising target for advancements in both imaging and therapeutic interventions. TSPO is a small protein located in the outer membrane of mitochondria, playing crucial roles in various cellular functions, including steroidogenesis, inflammatory responses, and cell survival. Notably, TSPO expression levels increase in response to neurological injuries and diseases, positioning it as a potential biomarker for neuroinflammation and recovery processes.

Understanding where drugs bind to this target is crucial for developing effective treatments. By studying the structure and behaviour of these binding sites, enables the optimisation of drug candidates for better affinity and selectivity. Additionally, natural variations in the TSPO protein can affect how drugs work. Therefore, exploring TSPO binding and the factors that influence it is essential for creating effective drug molecules. This presentation will use the TSPO as a case study to highlight these important considerations and showcase initiatives such as MedChem Australia and the NSW Organoid Innovation Centre, which aim to facilitate clinical translation.