PDRC is currently working on the following projects:
Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterization of new therapeutic targets for dementia prevention and treatment
Funding source: NHMRC Senior Research Fellowship (1109831) (2016-2020)
Researchers: B. Garner
Defining systems that clear dangerous misfolded proteins from body fluids
Funding source: ARC Discovery Project (2016-18)
Researchers: MR Wilson & H Ecroyd
Developing insight into the molecular origins of familial and sporadic front temporal dementia and amyotrophic lateral sclerosis
Funding source: NHMRC Dementia teams grant (2015-19)
Researchers: I Blair, J Atkin, R Chung, G Guillemin, L Ooi, W Wilson, M Molloy, JJ Yerbury, N Cole, T Karl
The role of mutant cyclin F in amyotrophic lateral sclerosis
Funding source: NHMRC Project (2016-18)
Researchers: I Blair, J Atkin, R Chung, JJ Yerbury, L Ooi
Ubiquitin Depletion as a Cause of Amyotrophic Lateral Sclerosis (ALS).
Funding source: MNDRIA Grant in Aid (2016)
Researchers: Saunders DN, Yerbury JJ
Development of a biocompatible functionalised liposome drug delivery system to increase the efficiency of delivery to motor neurons
Funding source: MNDRIA Grant in Aid (2016)
Researchers: Yerbury JJ, Perrow KL
Delivery of Ubiquitin to Motor Neurons Using a targeted sterically stabilised liposome delivery system
Funding source: USA Department of Defense (2016-17)
Researchers: Yerbury JJ, Perrow KL, Saunders DN
Proteome homeostasis dysfunction in axon terminals as a cause of MND
Funding source: Betty Laidlaw MND research prize (2018)
Researchers: Yerbury JJ, Ooi L, Blair I, Molloy M, Vendruscolo M
Developing a folding sensor to study chaperone protein function by single-molecule fluorescence techniques
Funding source: Australian post-graduate scholarship
Researchers: C Johnston (PhD student), AM van Oijen and H Ecroyd
Establishing the role of proteostasis pathways in preventing protein aggregation in cells
Funding source: Australian post-graduate scholarship
Researchers: S McMahon (PhD student), JJ Yerbury & H Ecroyd
Using single-molecule techniques to study how chaperone proteins prevent protein misfolding and aggregation
Funding source: Australian post-graduate scholarship
Researchers: C Johnston (PhD student), AM van Oijen and H Ecroyd
Investigating the structural and functional consequences of disease-related mutations in the small heat shock protein Hsp27
Funding source: Australian post-graduate scholarship
Researchers: A Rote (PhD student) & H Ecroyd